Many, many athletes take anabolic steroids, which can produce some serious cardiovascular damage as well as damage to other organs such as the liver. One of the early anabolic steroids, Dianabol, has been responsible for damaging organs of many of the bodybuilders of the 1960s and 1970s.
Smoking marijuana increases the heart rate by 50% and can cause chest pain to those who have a poor blood supply to the heart. Cocaine has powerful negative effects upon the heart, sometimes causing sudden death. For instance, cocaine increasing heart and blood pressure while constricting the arteries supplying blood to the heart. The result can be a heart attack, even in a young person without any heart disease. Cocaine can also trigger an abnormal heart rhythm, called arrhythmia, killing instantly.
By the way, some cancer drugs, if used for a long time, can cause heart damage. Prolonged usage of anthracyclines can lead to heart muscle damage, including cardiomyopathy, a condition that causes abnormal growth of muscle fibers. If the anthracyclines are continued, eventually they can lead to congestive heart failure.
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