ALX, or Alexander disease, is discovered in 1949 by the Australian pathologist W. Stewart Alexander, who reported about an infantile case.
This disease is synonymous with von Willebrand disease.
Rare form of leucodystrophy in infants, characterized by macrocephaly with encephalopathy and hydrocephalus.
The aetiology is uncertain: immaturity cells would prevent nerve fibers to be wrapped up by myelin during nerve development, as usually happens. Grim prognosis, with death by the age of two years.
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