Sunday, November 13, 2011

How are memory cells produced?A child is given a measles vaccination. Explain how the child becomes immune to measles.I have answered this question...

Immune memory involves specialized functional types of lymphocytes T and Bm, called memory cells .


B memory lymphocyte antigen receptors have higher binding antigens affinity  and therefore are more effective in capturing small amounts of antigens and presenting them faster.


Memory B cell generation mechanism is hypothetical. One theory believes that both plasma cells (antibody producing) and memory B cells are derived from the same B lymphocyte precursors.


Cells resulting from successive divisions, triggered by antigenic stimulation evolve differently: some are differentiated plasma cells, others remain small lymphocytes, returning to the G0 state and become memory lymphocytes. Descendants of stimulated clone  to evolve towards plasma cells or memory cell, compared with the influences it receives  from accessory cells or Th cells.


After another theory, the memory cells and plasma cells are comming from different B cells. B lymphocytes seem to be preprogrammed to become plasma cells or memory lymphocytes before antigen exposure.


Secondary immune response is characterized by increasing antibody affinity.


Memory Th cells are probably generated in the cortex of lymph nodes, but the mechanism is unknown. The memory T cells mechanism was proposed after the model of contact dermatitis induction, a delayed hypersensitivity reaction, mediated by CD4 cells.

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